Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
glr_human 22 N-term Q => Ter stop gained 5.936e-05 1 16846 0 None None
glr_human 463 C-term T => Ter stop gained 6.737e-05 1 14844 0 None None PTM (Phosphorylation)
glr_human 3 N-term P => S missense 6.489e-05 1 15410 0 nan 0.242
glr_human 8 N-term R => Q missense 6.508e-05 1 15366 0 0.07 0.009
glr_human 26 N-term A => T missense 0.0001183 2 16908 0 0.03 0.987
glr_human 29 N-term M => T missense 5.919e-05 1 16894 0 0.16 0.09
glr_human 40 N-term G => S missense 0.008359 140 16748 1 0.58 0.02
glr_human 41 N-term D => E missense 5.987e-05 1 16702 0 0.41 0.039
glr_human 54 N-term T => M missense 0.0001221 2 16382 0 0.0 0.961
glr_human 60 N-term R => T missense 5.739e-05 1 17426 0 0.0 0.997
glr_human 76 N-term T => M missense 0.0005184 9 17360 0 0.0 0.999
glr_human 88 N-term H => N missense 5.809e-05 1 17214 0 0.06 0.067
glr_human 96 N-term V => E missense 6.255e-05 1 15988 0 0.0 0.999
glr_human 103 N-term D => N missense 6.224e-05 1 16068 0 0.11 0.534
glr_human 111 N-term R => Q missense 6.178e-05 1 16186 0 0.33 0.029
glr_human 114 N-term P => A missense 0.00166 27 16266 0 0.1 0.058
glr_human 123 N-term M => I missense 6.073e-05 1 16466 0 0.28 0.02
glr_human 125 N-term G => C missense 0.0003036 5 16468 0 0.04 0.77
glr_human 128 N-term I => M missense 6.05e-05 1 16528 0 0.16 0.036
glr_human 140 1.38x38 TM1 S => N missense 5.895e-05 1 16964 0 0.17 0.069
glr_human 155 1.53x53 TM1 A => T missense 5.926e-05 1 16876 0 0.24 0.429
glr_human 159 1.57x57 TM1 A => T missense 5.962e-05 1 16772 0 0.0 1.0
glr_human 209 ECL1 D => N missense 5.788e-05 1 17278 0 0.14 0.733
glr_human 220 3.25x25 TM3 A => V missense 5.869e-05 1 17040 0 0.07 0.275
glr_human 221 3.26x26 TM3 V => L missense 0.0004097 7 17086 0 0.34 0.03
glr_human 225 3.30x30 TM3 R => H missense 0.0009872 17 17220 1 0.0 0.996
glr_human 228 3.33x33 TM3 A => T missense 5.769e-05 1 17334 0 0.36 0.054
glr_human 228 3.33x33 TM3 A => V missense 5.756e-05 1 17374 0 0.41 0.526
glr_human 236 3.41x41 TM3 V => M missense 5.496e-05 1 18196 0 0.14 0.21
glr_human 249 3.54x54 TM3 L => V missense 5.288e-05 1 18912 0 0.0 0.957 SodiumPocket MicroSwitch GP (contact)
glr_human 251 3.56x56 TM3 N => K missense 5.382e-05 1 18582 0 0.12 0.281
glr_human 262 4.40x41 TM4 S => R missense 5.65e-05 1 17698 0 0.26 0.151
glr_human 280 4.58x58 TM4 V => I missense 0.0001143 2 17498 0 1.0 0.005
glr_human 287 4.65x65 TM4 C => Y missense 5.716e-05 1 17494 0 1.0 0.028
glr_human 290 4.68x68 TM4 E => K missense 0.0002286 4 17496 0 0.0 0.974
glr_human 299 ECL2 D => N missense 5.806e-05 1 17224 0 0.22 0.014
glr_human 307 5.39x39 TM5 L => P missense 0.0001161 2 17230 0 0.03 0.17 LB (Van der Waals)
glr_human 311 5.43x43 TM5 V => I missense 5.811e-05 1 17210 0 1.0 0.88 SodiumPocket MicroSwitch LB (Van der Waals, hydrophobic)
glr_human 319 5.51x51 TM5 F => L missense 5.883e-05 1 16998 0 0.06 0.105
glr_human 322 5.54x54 TM5 F => L missense 0.0005269 9 17082 0 0.0 1.0 SodiumPocket MicroSwitch
glr_human 323 5.55x55 TM5 V => I missense 5.853e-05 1 17086 0 1.0 0.022
glr_human 326 5.58x58 TM5 V => I missense 0.0001168 2 17124 0 0.88 0.008
glr_human 336 ICL3 R => Q missense 0.001352 23 17016 0 0.07 0.551
glr_human 346 6.37x37 TM6 R => W missense 0.0001201 2 16654 0 0.0 1.0 GP (contact)
glr_human 358 6.49x49 TM6 L => V missense 0.0001234 2 16208 0 0.01 0.873 SodiumPocket MicroSwitch
glr_human 368 6.59x59 TM6 V => M missense 0.0001815 3 16528 0 0.02 0.987
glr_human 376 7.33x32 TM7 T => N missense 6.037e-05 1 16564 0 0.0 0.976
glr_human 380 7.37x36 TM7 A => T missense 6.015e-05 1 16626 0 0.23 0.037
glr_human 391 7.48x47 TM7 F => L missense 6.044e-05 1 16544 0 0.02 0.999 SodiumPocket MicroSwitch
glr_human 398 7.55x55 TM7 V => I missense 0.0001168 2 17126 0 nan 0.005
glr_human 409 8.52x52 H8 S => W missense 6.862e-05 1 14574 0 0.01 0.927
glr_human 412 8.55x55 H8 R => W missense 0.0001346 2 14864 0 nan 0.001
glr_human 412 8.55x55 H8 R => L missense 6.626e-05 1 15092 0 1.0 0.0
glr_human 413 8.56x56 H8 R => W missense 0.0002627 4 15226 0 0.0 0.724
glr_human 414 8.57x57 H8 R => H missense 0.001217 19 15616 0 0.08 0.002
glr_human 416 8.59x59 H8 H => R missense 0.0006272 10 15944 0 0.8 0.001
glr_human 416 8.59x59 H8 H => L missense 0.0001254 2 15944 0 0.13 0.035
glr_human 419 8.62x62 H8 R => S missense 0.0001225 2 16332 0 0.01 0.097
glr_human 419 8.62x62 H8 R => L missense 6.092e-05 1 16414 0 0.03 0.005
glr_human 419 8.62x62 H8 R => H missense 6.092e-05 1 16414 0 0.08 0.003
glr_human 428 8.71x71 H8 R => Q missense 0.0006449 11 17056 0 0.26 0.004
glr_human 438 C-term S => L missense 0.001914 33 17244 0 0.35 0.0 PTM (Phosphorylation)
glr_human 440 C-term G => S missense 0.0001158 2 17272 0 nan 0.003
glr_human 440 C-term G => R missense 5.79e-05 1 17272 0 nan 0.005
glr_human 452 C-term R => K missense 5.767e-05 1 17340 0 0.7 0.002
glr_human 456 C-term S => T missense 5.764e-05 1 17348 0 0.09 0.08 PTM (Phosphorylation)
glr_human 457 C-term Q => R missense 0.0001153 2 17342 0 0.69 0.002
glr_human 458 C-term D => H missense 0.002479 43 17344 0 0.03 0.546
glr_human 461 C-term A => V missense 0.0003461 6 17338 0 0.07 0.003
glr_human 469 C-term L => F missense 0.0001157 2 17288 0 nan 0.646
glr_human 476 C-term P => L missense 0.0001169 2 17112 0 nan 0.024


Residue

Diagrams

ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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